Peter Burke, MD, FACS, Chief of Trauma Surgery at Boston Medical Center, recently published an article, Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α, in the journal BMC Genomics.
Abstract: Hepatocyte nuclear factor 4α (HNF4α), a liver-specific transcription factor, plays a significant role in liver-specific functions. However, its functions are poorly understood in the regulation of the inflammatory response. In order to obtain a genomic view of HNF4α in this context, microarray analysis was used to probe the expression profile of an inflammatory response induced by cytokine stimulation in a model of HNF4α knock-down in HepG2 cells.
The article can be viewed by clicking here.